QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

NF-B: a novel target for ß₃-endonexin

ß₃-endonexin is an integrin-binding protein that binds specifically to the cytoplasmic tail of integrin ß₃. The protein is thought to participate in integrin recycling but might also regulate cell cycle progression, since it can bind to cyclin A and inhibit the activity of cyclin-dependent kinase 2 (CDK2). Meinrad Gawaz and co-workers now show that ß₃-endonexin can also interact with another important cellular regulator: the transcription factor NF-B (see p. 3879). They demonstrate that integrin-ß₃-dependent repression of the urokinase-type plasminogen receptor (uPAR) gene can be mimicked by overexpression of ß₃-endonexin and that this requires the NF-B-binding site in the uPAR promoter. The authors also find that ß₃-endonexin splice forms contain a KRKK sequence that allows them to translocate to the nucleus. Furthermore, they show that ß₃-endonexin physically associates with the p50-p65 NF-B complex in vivo and can interfere with its binding to oligonucleotides containing the NF-B consensus sequence. These findings thus not only reveal a nuclear role for this integrin-associated protein but also provide evidence for a novel adhesion-dependent mechanism for NF-B regulation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Role of ß₃-endonexin in the regulation of NF-B-dependent expression of urokinase-type plasminogen activator receptor

Felicitas Besta, Steffen Massberg, Korbinian Brand, Elke Müller, Sharon Page, Sabine Grüner, Michael Lorenz, Karin Sadoul, Waldemar Kolanus, Ernst Lengyel, and Meinrad Gawaz
JCS 2002 115: 3879-3888. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?