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LGP85 and endosome maintenance

Lysosomes and late endosomes are thought to exist in dynamic equilibrium, undergoing repeated cycles of fission and fusion. Their limiting membranes contain a common set of highly glycosylated transmembrane proteins, including LAMP-1, LAMP-2 and LGP85 (also known as LIMP-II). Whether these proteins are involved in endosome/lysosome dynamics or play some other role is unclear. To investigate the possibility, Yoshitaka Tanaka and co-workers have overexpressed them in COS cells. They observe that overexpression of LGP85 (but not LAMP-1 or LAMP-2) induces formation of abnormally large endosome-like structures (see p. 4117). Transport of cargo out of these structures is blocked, and they accumulate free cholesterol. Interestingly, the authors show that coexpression of a dominant-negative form of Rab5b (a GTPase that functions in endosomal/lysosomal membrane trafficking) inhibits the effect of LGP85, implicating the GTPase in formation of the large endosomes. Tanaka and co-workers thus propose that LGP85 is important for the biogenesis and maintenance of endosomes/lysosomes and drives their reorganization by interacting with components of the vesicle fission/fusion machinery.

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A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology

Toshio Kuronita, Eeva-Liisa Eskelinen, Hideaki Fujita, Paul Saftig, Masaru Himeno, and Yoshitaka Tanaka
JCS 2002 115: 4117-4131. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?