Fig. 1. Alignment of general cell (GC) and striated muscle (SM) isoforms of human (hUNC-45) and mouse (mUNC-45) UNC-45. The TPR domain (red), central region (green) and UCS domain (purple) are indicated. Identity is indicated by black boxes, similarity by grey boxes. The GC and SM isoforms are 55-56% identical, while respective human and mouse isoforms are 94-95% identical. Intron/exon boundaries, indicated by arrowheads (blue for GC, red for SM), are identical for the same mouse and human isoform, and furthermore, are identical for homologous coding regions in GC and SM genes. Red asterisks indicate conserved residues corresponding to C. elegans temperature-sensitive UNC-45 mutations (Barral et al., 1998), and blue asterisks indicate S. pombe Rng3p mutations (Wong et al., 2000). Blue and red arrows indicate the chymotryptic and tryptic cleavage sites, respectively, present in C. elegans UNC-45 (J.M.B. and H.F.E., unpublished).

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