Fig. 1. The spectrin protein superfamily. Depicted is a selection of members of the spectrin family of proteins, comparing human and fly orthologues for each member, and in the case of spectraplakins showing both mammalian genes (MACF1 and BPAG1). The spectrin family members are arranged in a phylogenetic tree on the basis of the sequences of their calponin-homology type actin-binding domains. Protein domains detected by SMART analysis are shown in coloured boxes (Schultz et al., 1998).

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