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Fig. 7. Expression of islet-1 and components of the retinoid signalling pathway by in situ hybridisation in the lumbar cord of a normal (A,C,E) and an aged-matched patient suffering from spontaneous motoneuron disease (B,D,F). A,B, islet-1 expression; C,D, RAR{alpha} expression; E,F, raldh-2 expression. Arrows indicate motoneurons. The brown deposit is lipofuscin, which is expressed by aged neurons. This does not interfere with the quantitative analysis. The same data was obtained from nine other patients.





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