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Fig. 8. Graph showing the percentage of motoneurons in the lumbar cord expressing islet-1 and components of the retinoid signalling pathway in aged-matched normal and motoneuron disease patients. Columns: 1, islet-1-positive motoneurons in normal cord; 2, islet-1-positive motoneurons in diseased cord; 3, RAR{alpha}-positive motoneurons in normal cord; 4. RAR{alpha}-positive motoneurons in diseased cord; 5, raldh-2-positive motoneurons in normal cord; 6, raldh-2-positive motoneurons in diseased cord. Error bar=s.e.m. There was no significant difference between the percentage of islet-1 motoneurons in normal and diseased aged-matched samples (columns 1 and 2). There was a significant difference between the number of RAR{alpha}-positive motoneurons (columns 3 and 4) *P<0.01 and between the number of raldh-2-positive motoneurons (columns 5 and 6) **P<0.001 of normal and diseased aged-matched samples. Students t-test, n=10.





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