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Fig. 7. I{kappa}B{alpha}AS enhances NF{kappa}B transcriptional activity following UV, TNF-{alpha}, pervanadate or H/R treatment. HeLa cells were co-infected with Ad.NF{kappa}Bluc (500 particles/cell) together with either Ad.BglII or Ad.I{kappa}B{alpha}AS at an moi of 1000 particles/cell for 24 hours. Cells were treated with (A) UV (50 J/m2), (B) TNF-{alpha}(10 ng/ml), (C) pervanadate (50 µM) and (D) H/R (5 hours hypoxia, 6 hours reoxygenation). Luciferase assays were performed on samples harvested 6 hours after treatment. Results depict the mean (±s.e.m., n=6) raw unadjusted relative light units (RLU). NF{kappa}B transcriptional activity was significantly enhanced (P<0.01) in the Ad.I{kappa}B{alpha}AS infected groups, as compared to the groups infected by Ad.BglII, following UV, TNF-{alpha}, pervanadate or H/R treatment.





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