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Fig. 1. Identification of the DOCK180 superfamily of proteins. (C,D) Multiple sequence alignment of the DHR-1 (C) and DHR-2 (D) domains. DHR-1 and DHR-2 sequences from representative members of the human DOCK180 superfamily were aligned with ClustalW and the final output was generated by BoxShade. Black and gray shading indicate identical and similar residues, respectively. Identical residues are indicated in capital letters and similar residues in lower-case letters in the consensus sequence.





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