QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

The COP9 signalosome (p. 467)

The COP9 signalosome (CSN) is a protein complex whose eight subunits display significant sequence similarity to those of the 26S proteasome LID — a component of the 26S proteasome complex that degrades ubiquitin-conjugated proteins. What is the function of this LID-like structure? Wolfgang Dubiel and co-workers examine studies suggesting that it functions as a platform that connects signalling with proteolysis. First identified as being important for proper plant photomorphogenesis, the CSN appears to control many aspects of plant development. It is also implicated in regulation of the yeast cell cycle and fruitfly development. Recent work suggests that the CSN cooperates with the E3 ubiquitin ligase SCF to control stability of key cell cycle and developmental regulators. Furthermore, one of its subunits, CSN5, has been shown to interact with a variety of cellular regulators, including the CDK inhibitor p27^Kip1 and the transcription factor JUN. Indeed, such molecules might be targets of a CSN-associated kinase that targets them for degradation by the ubiquitin system.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis

Dawadschargal Bech-Otschir, Michael Seeger, and Wolfgang Dubiel
JCS 2002 115: 467-473. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?