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Fig. 4. Effects of TGF-ß superfamily members on pancreatic cell colony
formation. Colonies (mean±s.d., n=3 separate experiments) were
counted 6 days after culture with the indicated treatment in the presence of
160 µg/ml laminin-1. (A) Effect of BMP-6, activin A, TGF-ß1 (all 100
ng/ml) or vehicle alone. (B) Effect of BMP-5, activin A or TGF-ß1 (each
100 ng/ml) on BMP-6 (10 ng/ml)-induced colonies. (C) Dose-dependent inhibition
by TGF-ß1 and activin A of BMP-6 (10 ng/ml)-induced colonies.
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