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Nuclear diacylglycerol and PKC-ß_II import at G2/M (p. 983)

In G2/M phase, PKC-ß_II translocates to the nucleus, where it is proposed to stimulate disassembly of the nuclear lamina by phosphorylating lamin B₁. But PKC-ß_II is just one of a host of cellular PKC isoforms. How do cells selectively translocate PKC-ß_II? Janet Lord and co-workers have addressed this question by analysing the levels of potential PKC-activating lipids in nuclei during the cell cycle; they used centrifugal elutriation to isolate cells at different stages of the cell cycle and thereby avoid the use of cell cycle inhibitors. The authors find that nuclear translocation of PKC-ß_II correlates with an increase in the levels of nuclear diacylglycerol - in particular the tetraunsaturated species 1-stearoyl, 2-arachidonyl glycerol (SAG). They show that SAG potently activates PKC- and PKC-ß_II but not the novel isoform PKC-. Lord and co-workers propose that generation of nuclear SAG at G2/M facilitates association of PKC-ß_II with the nuclear membrane - perhaps as part of a general mechanism for differential control of PKC signalling by distinct forms of diacylglycerol.

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Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-ßII at G2/M

Elizabeth M. Deacon, Trevor R. Pettitt, Paul Webb, Timothy Cross, Hema Chahal, Michael J. O. Wakelam, and Janet M. Lord
JCS 2002 115: 983-989. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?