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Fig. 3. Survival of DNA-ligase-I-deficient cells exposed to the following DNA damaging agents (A) UV; (B) EMS; (C) 3-aminobenamide (3-AB); and (D) {gamma}-irradiation. Mean survival±s.e.m. is shown relative to non-treated controls. {blacksquare}, mouse wild-type (PF20); {blacktriangleup}, mouse Lig1 null (PFL13); {blacktriangledown}, mouse Lig1 null (PFL10); {square}, human wild-type (MRC5); {circ}, human LIG1 point mutant (46BR); closed hexagon, mouse Ercc1 null (PF24).





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