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Laser-induced muscle regeneration

Adult skeletal muscle in humans has a limited ability to repair itself. The development of therapies that promote muscle regeneration is therefore an important goal of research into myopathies and muscle trauma. One potential approach is low-energy laser irradiation (LELI). LELI has been shown to facilitate wound healing and muscle regeneration; the next step is to establish the underlying mechanism. Orna Halevy and co-workers have analysed the effects of LELI on explanted single fibres, which comprise contractile fibres and associated satellite cells and therefore closely mimic skeletal muscle in vivo (see p. 1461). The authors find that LELI induces the normally quiescent satellite cells to enter the cell cycle and proliferate. Moreover, LELI also promotes cell survival, stimulating expression of the anti-apoptotic protein Bcl-2 and reducing the levels of its pro-apoptotic counterpart BAX. Since the increase in cell proliferation and inhibition of apoptosis are not long term (and hence unlikely to reflect transformation), Halevy and co-workers conclude that LELI could provide a safe and effective treatment for muscle injury/myopathy.

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Related articles in JCS:

Low-energy laser irradiation promotes the survival and cell cycle entry of skeletal muscle satellite cells

Gavriella Shefer, Terry A. Partridge, Louise Heslop, Jacqueline G. Gross, Uri Oron, and Orna Halevy
JCS 2002 115: 1461-1469. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?