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An actin template for cytokeratin organization

Interactions between the three major cytoskeletal filament systems are critical for normal cell function. Interactions between actin and microtubules, for example, underpin cell migration; similarly, association with microtubules appears to be important for translocation of intermediate filaments (IFs). But to what extent do IFs and actin interact? Kari Weber and William Bement have addressed this question, using Xenopus egg extracts to avoid problems presented by multipolymer analysis in intact cells (see p. 1373). They show that cytokeratin assembles on and moves in concert with forming actin cables. If actin assembly is blocked, the IF forms disorganized aggregates rather than cables. Such actin-directed IF assembly is probably relevant in vivo, since disruption of the actin cytoskeleton induces formation of cytokeratin aggregates in intact eggs. Interestingly, the authors show that during later stages of assembly cytokeratin often dissociates from F-actin to form independent networks. They therefore conclude that F-actin acts as a template for assembly of a cytokeratin network in these cells but is not necessarily important for its maintenance.

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F-actin serves as a template for cytokeratin organization in cell free extracts

Kari L. Weber and William M. Bement
JCS 2002 115: 1373-1382. [Abstract] [Full Text]  

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?