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Fig. 6. Changes in protein expression associated with cardiac hypertrophy in transgenic hearts. Western blot analysis of heart lysates from 3-day- to 4-week-old wild-type and {alpha}MHC/Ncad (A) and {alpha}MHC/Ecad (B) transgenic mice shows the time course of the expression of the transgene in relation to other intercalated disc proteins. Note the dramatic decrease in Cx43 protein in the 4-week-old {alpha}Ecad heart compared with {alpha}Ncad, consistent with the severe hypertrophy response caused by E-cadherin. GAPDH signal shows loading of samples between lanes. tg, transgene; d, days; w, weeks.





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