Fig. 9. Model of Sla 1p coupling actin dynamics and endocytosis. Our data indicate that in wild-type cells Sla 1p is able to interact both with proteins regulating actin dynamics and with proteins forming part of the endocytic machinery. Sla 1p localisation at the cell cortex is shown to be largely dependent on the presence of functional End3p, a protein of the endocytic machinery, but a subset of complexes containing Sla 1p can also localise with Abp 1p-actin structures. We propose that it is in this larger complex that Sla 1 binding to Abp 1p and Las 17p/Bee 1p is able to link actin dynamics with the endocytic machinery and thereby facilitate endocytosis.

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