spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content
Journal of Cell Science 115, e804-e804 (2002)
© 2002 The Company of Biologists Limited

In this issue

CAP1 and actin treadmilling


Actin treadmilling — the continuous removal of actin monomers from the pointed ends of filaments and their reincorporation at barbed ends — is essential for cell motility. The process is accelerated by the actin-binding protein ADF/cofilin, which stimulates the release of actin monomers from pointed ends. Kenji Moriyama and Ichiro Yahara have investigated the role of another factor that could play a role in treadmilling — CAP1 — an adenylyl-cyclase-binding protein whose C-terminus has been shown to inhibit actin polymerization (see p. 1591). They show that CAP1 is part of a complex that contains ADF/cofilin, actin-interacting protein 1 (Aip1) and actin. In addition, they show that the CAP1 N-terminus can stimulate removal of actin from the pointed ends of filaments whereas the C-terminus promotes filament assembly at barbed ends. Another important finding is that the CAP1 N- and C-termini cooperate to relieve cofilin-mediated inhibition of ADP-ATP exchange on G-actin. This is likely to increase the availability of easily polymerizable monomers and indicates that during treadmilling CAP1 has important roles in both actin depolymerization and recycling.


Related articles in JCS:

Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover
Kenji Moriyama and Ichiro Yahara
JCS 2002 115: 1591-1601. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content