Fig. 4. Effect of polyclonal anti-UPA antibodies on S phase entry of vascular SMC stimulated with PDGF or bFGF. Growth arrested vascular SMC exposed to 20 ng/ml PDGF or 10 ng/ml bFGF in the absence or presence of anti-UPA antibodies (40 µg/ml) received 6 hour pulses of BrdU after (A) 12 hours and (B) 18 hours of stimulation. The BrdU-labeling index was calculated as described in Fig. 3. Results from five independent experiments are given as data points. Each individual point corresponds to the mean value of triplicate determinations. Points linked by lines represent data from the same experiment obtained in the absence or presence of anti-UPA antibodies. Analysis of significance for differences within pairs in each group was performed by the Wilcoxon matched-pair signed rank test (P=0.031 for each group).

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