Journal of Cell Science 115, e905-e905 (2002)
© 2002 The Company of Biologists Limited
A map of the exocytic pathway
The transport of cargo from the endoplasmic reticulum to its destination
inside or outside the cell involves a host of vesicle coats, GTPases and
specialized docking/fusion proteins. It is hard enough to keep track of the
various COPs, ARFs, Rabs and SNARES - let alone their yeast homologues, many
of which are distinguished only by a `Sec' number. But help is at hand. In
Cell Science at a Glance (see p.
1779 and the accompanying poster), Sophie Béraud-Dufour and
William Balch provide an invaluable navigation aid: a map of the exocytic
pathway. Their expanded poster comprises three panels: the Arfs, which are
involved in vesicle formation; the Rabs, which function in vesicle targeting;
and the SNAREs, which drive vesicle fusion. They also include examples of
additional known effectors and models for individual transport steps. Planning
a route from synthesis to secretion has never been so easy.
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Related articles in JCS:
- A journey through the exocytic pathway
- Sophie Béraud-Dufour and William Balch
JCS 2002 115: 1779-1780.
[Full Text]
