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Rethinking centriole duplication

Centrioles, like DNA, replicate exactly once every cell cycle. The daughter centriole grows out at right angles from the existing centriole, ultimately becoming an exact replica of its mother. The underlying mechanism probably involves nucleated self-assembly, but how this generates a perfect copy, and what regulates the process, remains a mystery. Patrick O'Farrell and co-workers now implicate the mitotic kinase, CDK1, in control of centriole replication (see p. 137). They have used transmission electron microscopy (TEM) to examine centrioles in the wing discs of Drosophila expressing a temperature-sensitive CDK1 mutant. At the nonpermissive temperature, three unusual centriole configurations are apparent: (1) centriole triplets in which one mother is associated with two daughters; (2) centriole triplets comprising a grandmother, a mother and a daughter; and (3) centriole pairs in which the daughter is longer than the mother. The authors' observations challenge the prevailing notions that centrioles possess only one site for daughter assembly and that mother and daughter must separate before a new centriole can be synthesized. Moreover, they reveal that regulatory mechanisms, rather than structure, can define features of centrioles such as their length and number.

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Related articles in JCS:

Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation

Smruti J. Vidwans, Mei Lie Wong, and Patrick H. O'Farrell
JCS 2003 116: 137-143. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?