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A trafficking role for synaptotagmin III

Among the numerous different protein families implicated in control of membrane trafficking are the synaptotagmins. These are large integral membrane proteins that bind to phospholipids and the t-SNAREs syntaxins. Synaptotagmin I and synaptotagmin II are thought to function in neurotransmitter release and lysosomal exocytosis, respectively, but precious little is known about what the other 11 members of this family do. Ronit Sagi-Eisenberg and co-workers have now studied the role of synaptotagmin III, which is expressed in mast cells (see p. 145). Colocalizing the protein with markers proteins such as EEA1 and histamine, they show that it is present on early endosomes and secretory granules. They then use an antisense cDNA approach to reduce synaptotagmin III levels: although this has no effect on uptake of cargo (transferrin) into early endosomes, it does block transport from early endosomes to the perinuclear endocytic recycling compartment (ERC) and also generates enlarged secretory granules. The authors therefore conclude that synaptotagmin III is critical for transport of cargo from early endosomes to the ERC. Furthermore, given the effect on secretory granules, they suggest it is part of a novel mechanism for recycling of material from immature secretory granules to the ERC during their maturation.

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Related articles in JCS:

Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size

Elena Grimberg, Ze Peng, Ilan Hammel, and Ronit Sagi-Eisenberg
JCS 2003 116: 145-154. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?