Fig. 7. SG in control and RBL-Syt III^- cells. (A) Electron micrographs of a control (empty vector transfected) RBL cell and a RBL-Syt III^- cell. The arrow points to a `giant' granule depicted in the RBL-Syt III^- cell. (B) Distribution of measured granule cross-sectional profile areas of RBL-Syt III^- (lower panel) and control cells (upper panel). Both histograms are statistically different based on the Kolmogorov-Smirnov test (P<0.01). A histogram of moving-bin analysis demonstrating multimodal frequency of RBL granule equivalent volumes derived from both cell lines is depicted at the upper inset. The value of this mode is calculated from the inter-modal spacing and is indicated by arrowheads (unit granule volume=0.083 µm³). The second inset (lower panel) represents a scattergram analysis of mean granule profile area and its standard deviation for each cell profile.

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