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Fig. 6. Properties of intercellular channels formed from Cx43.4 are similar to
Cx45. N2A cells were transiently transfected with Xenopus Cx43.4 and
analyzed by dual whole-cell voltage clamping. (A) Time-dependent inactivation
of junctional currents in response to transjunctional potentials; 5 seconds
long, 20 mV steps between -100 and +100 mV are shown. (B) Normalized
steady-state conductance plotted against transjunctional voltage closely
matches a double Boltzman distribution (N=7; V0=
20 mV;
Gmin/Gmax=0.05). (C) Single channel recordings display 35 pS transitions.
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