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Fig. 3. Regulation of eNOS in caveolae. Myristoylation and palmitoylation (jagged lines) target eNOS to plasma membrane caveolae. Interaction with caveolin inhibits eNOS activity. Endothelial cell stimuli such as shear stress, recruit Hsp90 and activate eNOS by recruiting calcium and calmodulin (CaM). Phosphorylation of eNOS by Akt also increases activity.





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