Fig. 3. Structure of human TSG-6. A representation of the modular structure of the mature TSG-6 protein is shown with amino acid positions indicated on the basis of the preprotein sequence (Lee et al., 1992): contiguous Link and CUB (Complement subcomponents C1r/C1s, Uegf, BMP-1) modules are flanked by a 19 amino-acid N-terminal sequence and a 27 amino-acid C-terminal sequence. The refined solution structure of the Link module (C. D. Blundell, I. D. Campbell and A.J.D., unpublished; PDB accession code 1o7b) and a model of the Gln¹⁴⁴ allotype of the CUB domain (Nentwich et al., 2002) are depicted below. The five amino acids identified as being involved in HA binding (Mahoney et al., 2001) are highlighted in purple on the Link module and the polymorphic residue (position 144) (Nentwich et al., 2002) is marked on the CUB module. The point of connection between the Link and CUB modules is indicated by a dashed line (their relative orientations remain to be determined) and the locations of the N- and C-terminal sequences, which are of unknown structure, are indicated.

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