|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
|
Fig. 5. Auto-inhibition of kinesin I motor activity by folding. In the absence of
cargo, kinesin I is in a folded conformation wherein the C-terminus of KHC
interacts with the motor domain to prevent binding to the microtubule. How
kinesin I is activated is unknown. One hypothesis is that cargo binding (to
either the KLC or the KHC cargo binding sites) induces a conformational change
that frees the motor domain to engage the microtubule.
|
