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Fig. 2. Schematic representation of human filamin-2 domain structure
(Thompson et al., 2000;
van der Ven et al., 2000b;
Xie et al., 1998), indicating
the 24 Ig repeats, the actin binding domain, and the hinge region. The regions
encoded by the mouse filamin-2 cDNA clones isolated in the yeast two-hybrid
screen for N-RAP binding partners are shown below. Restriction enzyme analysis
placed the 15 clones into seven groups of 1-6 clones each, and a total of
eight of these clones were end-sequenced. The shortest mouse clones align with
Ig repeats 20-24 of the human filamin-2 protein.
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