QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

MHC-II molecules and lipid rafts

MHC class II (MHC-II) molecules are best known for their function in antigen presentation – they promote T cell activation by displaying processed antigenic peptides on the surface of monocytes and other antigen-presenting cells. These cell surface molecules also have a lesser known signalling function, however, transmitting signals to tyrosine kinases and protein kinase C (PKC) that stimulate cell proliferation, cytokine release and apoptosis. Nuala Mooney and co-workers now delve further into MHC-II signalling (see p. 2565). They demonstrate that, in solid tumors expressing the MHC-II molecule I-A^k, engagement of I-A^k induces its recruitment to the detergent-insoluble glycolipid (DIG) fraction of the membrane – i.e. lipid rafts. The authors go on to show that PKCa is recruited to these rafts, and activated, when I-A^k is engaged. Furthermore, they show the disruption of the rafts by depletion of cholesterol blocks recruitment and activation of PKCa, as well as the actin rearrangements that occur during MHC-II signalling. These experiments thus reveal a critical role for lipid rafts in signalling by MHC-II molecules, placing recruitment of these molecules upstream of early signalling events such as PKC activation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Intracytoplasmic domains of MHC class II molecules are essential for lipid-raft-dependent signaling

Stéphane Bécart, Niclas Setterblad, Suzanne Ostrand-Rosenberg, Santa J. Ono, Dominique Charron, and Nuala Mooney
JCS 2003 116: 2565-2575. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?