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Fig. 1. Integrin-mediated activation of the Arp2/3 complex. Left, in the absence of
integrin engagement or other stimuli, Rac and Cdc42 are held in an inactive
GDP-bound state. WAVE-1 exists in an inactive, heterotetrameric complex with
HSPC, NAP125 and PIR. Right, integrin ligation triggers the exchange of GDP
for GTP. Cdc42 binds and induces a conformational change in WASP that permits
it to bind and activate the Arp2/3 complex. Rac and NCK disrupt the WAVE
complex, causing it to disassemble and release WAVE in association with
HSPC300. WAVE binds and activates the Arp2/3 complex.
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