Fig. 6. Phylogenetic analyses of relationships based on comparisons of complete amino acid sequences representing 28 different RyRs and IP₃Rs. The analyses include the RyR and IP₃R from Drosophila melanogaster, the calcium release channels from other invertebrates as well as the three different vertebrate isoforms of these proteins from representative species. (A) Phylogram of the most parsimonius unrooted PHYLO_WIN tree recovered (1101 steps), where horizontal branch lengths are proportional to the amount of divergence along a lineage. The topology of this tree was identical to the Neighbor Joining tree (data not shown). In Panels A and B, RyR and IP₃R are depicted as `RyR' and `InsP3' followed by the type number (for vertebrate sequences) and the abbreviation of the species, respectively. (B) Unrooted cladogram illustrating the pattern of relationships. This tree was recovered following Bootstrap analysis (2 replicates). The number of each node indicates the percentage recovery for the node during resampling. Species code: Drosophila, Dm; C. elegans, Ce; blue marlin, Mn; pig, Ss; rabbit, Oc; human, Hs; mouse, Mm; bull frog, Rc; chicken, Gg; american mink, Mv; lobster, Pa; Wistar rat, Rn; cow, Bt; Xenopus, Xl.

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