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Fig. 3. Alignment of FERM domain sequences from PTPs and ezrin. The aligned FERM domains are human PTPH1 (hPTPH1), Caenorhabditis elegans PTP-FERM (PTP-FERM), human PTPL1 (hPTPL1) and human ezrin (hEzrin). Conserved amino acid residues from at least two sequences are highlighted in black when identical or in gray when encompassing to the same family. Bold bars represent localization of the two PtdIns(4,5)P2-binding motifs identified in ezrin. Subdomains A, B and C of ezrin are indicated by thin bars.





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