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Fig. 2. Forward and reverse signals communicated downstream of the Eph-ephrin
complex. Some of the known EphA—ephrin-A or EphB—ephrin-B
signaling pathways are highlighted. Note that SH2 and PDZ refer to a number of
identified proteins containing SH2 or PDZ domains. Grb4 is the only
SH2-domain-containing protein known to bind to ephrins.
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