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Fig. 5. Activation and nuclear translocation of Dd-STATc in response to
membrane-permeant cyclic nucleotide analogues. (A) The tyrosine
phosphorylation of Dd-STATc was determined in untreated cells (cont), cells
exposed to 200 mM sorbitol (sorbitol) and in cells exposed to the indicated
concentrations of membrane-permeant cyclic nucleotide analogue. Induction was
for 3 minutes and the samples were analysed as described in
Fig. 2. (B) The activation and
(C) the nuclear translocation of Dd-STATc in response to 20 mM 8-bromo-cAMP
and 8-bromo-cGMP were determined as described in
Fig. 2. The results in panel C
are shown as the mean±s.d.
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