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Fig. 3. Some mutant lamins form nuclear foci in MEFs (lmna-/-)
and emerin co-localizes with foci formed by `rod' mutants but not `tail'
mutants. Transfection of MEFs (lmna-/-) with lamin A N195K
(A), E358K (B) or L85R (C) produced nuclear foci that were also positive for
emerin (L85R produced foci only rarely;
Table 1). Similar results were
obtained with R386K and M371K (not shown). Two of the three `tail' mutants,
R453W (D) and R527P (E), produced nuclear foci only rarely and these did not
accumulate emerin (arrows). Bars, 10 µm.
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