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Fig. 7. Co-transfection with wild-type and mutant lamin A prevents or greatly reduces nuclear focus formation. MEFs (lmna-/-) (A) and COS-7 cells (B) were co-transfected with pSVK3/lamin A N195K and pcDNA4/lamin A wild-type. The two lamins were detected with anti-FLAG polyclonal and anti-Xpress monoclonal antibodies, respectively. Nuclear foci were not seen with the MEFs (lmna-/-). Nuclear foci (arrows) were very rarely seen with COS-7 cells (B) and these foci were positive for wild-type and mutant lamin A. Bars, 10 µm.





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