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Fig. 7. Proposed signaling scheme shows PLD involvement in stimulated PIP2 production upstream of IP3-mediated Ca2+ release from stores in RBL cells. See text for details. Also indicated are the minimal steps required for Fc{epsilon}RI-mediated exocytosis: PLC{gamma} activation leading to sustained Ca2+ mobilization initiated by IP3-mediated Ca2+ release from stores, together with diacylglycerol (DAG)-mediated activation of PKC.





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