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Fig. 5. Ultrastructure of primary melanocytes established from wild-type and from
uw-mutant mice. (A) Wild-type melanocytes showing numerous stage III and IV
melanosomes. (B) uw-mutant melanocytes displaying primarily stage I and II
melanosomes. (C) uw-mutant melanocytes incubated with DOPA show a dark
staining in stage I and II melanosomes (arrows), which proves the presence of
active tyrosinase. (D) Secreted vesicle fraction from uw-mutant melanocytes
where stage I and II melanosomes, similar to those found in (B), are
identified clearly. Bar, 20 µm.
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