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Fig. 4. (A) Involvement of the dynein-dynactin complex in MTOC targeting of Gag. In cells overexpressing CC1, the central coiled-coil domain of p150Glued, GFP-Gag is no longer able to reach the centrosome (top). By contrast, expression of CC1 does not disrupt the MT network (bottom). (B) Following nocodazole treatment, GFP-Gag is no longer linked to the pericentrosomal region but dispersed within the cytoplasm.





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