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Fig. 3. PP1 and aurora B. (A) The function of aurora B and PP1 in H3 Ser10 phosphorylation. Ser10 is phosphorylated by aurora B in mitosis and dephosphorylated by PP1 that can also dephosphorylate and inactivate aurora B. (B) Potential consensus sequences for the type 1 phosphatase-binding site in human aurora kinases. (C) Alignment of a segment of aurora B from C. elegans, D. melanogaster, X. laevis, M. musculus, R. norvegicus and H. sapiens containing the end of the kinase subdomain 1 and the conserved potential PP1-binding site.





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