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Fig. 6. Determinants affecting R-Ras targeting. HeLa cells were transiently transfected with pEGFP-R-Ras38V-NT (A,B), pEGFPHVR (C,D), pEGFP-R-Ras38V-dHVR (E,F), pEGFP-R-Ras38V-2PA (G,H), pEGFP-R-Ras38V-CA (I,J), pEGFP-R-Ras38V-SP (K,L) and pEGFP-R-Ras38V-dC (M,N), fixed and stained with anti-vinculin. Observe the absence of EGFP-HVR from vinculin-containing adhesions. Note the accumulation of R-Ras38V-dHVR, R-Ras38VCA in Golgi and R-Ras38V-SP in ER. EGFP-R-Ras38V-dC that lacks signals for lipid modifications is found in the nucleus.





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