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First published online September 2, 2003

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Journal of Cell Science 116, e1905 (2003)
Copyright © 2003 The Company of Biologists Limited

In this issue

DNA checkpoints


Cells must replicate and repair DNA before entering mitosis - to avoid the potentially catastrophic consequences of trying to segregate chromosomes containing unreplicated or damaged DNA. They therefore possess checkpoints that monitor completion of DNA replication and repair and delay mitosis if necessary. In Cell Science at a Glance (see p. 3847 + poster), Kanji Furuya and Anthony Carr survey the components of these checkpoints and the signalling pathways that they activate in fission yeast. Key effectors in these pathways are the effectors Chk1 and Cds1, both of which promote accumulation of a kinase (Mik1) that blocks mitosis by phosphorylating Cdc2.


Related articles in JCS:

DNA checkpoints in fission yeast
Kanji Furuya and Antony M. Carr
JCS 2003 116: 3847-3848. [Full Text]  



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[Abstract] [Full Text] [PDF]

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