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Nuclear ANChors

Correct positioning of the nucleus is critical in a variety of cell types, including nurse cells, intestinal brush-border cells, syncytia and all cells in which nuclear migration is required during development. Microtubules play an important part in nuclear positioning, as does the actin cytoskeleton. In a Commentary on p.211, Daniel Starr and Min Han discuss the importance of actin-based networks for nuclear anchorage, focusing on the roles of a novel family of proteins termed Syne/ANC-1. Studies in C. elegans have revealed that the UNC-84 and ANC-1 proteins are required for nuclear anchoring in the syncytial hypodermal cells. UNC-84 is a nuclear envelope protein, whereas ANC-1 is a huge evolutionarily conserved actin-binding protein. ANC-1 and its relatives, the Syne/ANC-1 family, appear to reside mainly in the cytoplasm, but they possess a C-terminal domain that localizes to the nuclear envelope. The majority of the protein, however, comprises repetitive stretches that could span >150 nm. Starr and Han propose that the C-terminal region is linked to UNC-84 in the nuclear membrane and anchors the nucleus to the actin cytoskeleton through this long, flexible domain.

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Related articles in JCS:

ANChors away: an actin based mechanism of nuclear positioning

Daniel A. Starr and Min Han
JCS 2003 116: 211-216. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?