Fig. 1. UNC-84 and ANC-1 are conserved. On the left, the family of SUN domain-containing proteins is depicted. The SUN domains (tan) are between 34 and 47% identical to the UNC-84 SUN domain. All of these proteins, except the Drosophila member (which might not be full length) have a predicted trans-membrane domain (pink). On the right, the Syne/ANC-1 proteins are depicted. The last 60 residues are the KASH domain (light blue) with a predicted trans-membrane domain (pink). These domains are between 50 and 60% identical to one another. The N-termini of these proteins contain two calponin-like domains of about 100 residues each (red). The large central region (blue) of ANC-1 consists of mostly novel repetitive stretches, while central regions of the others consist of mostly spectrin repeats. These domains are both predicted to form extended rod-like structures.

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