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Fig. 3. Is there a potential role for Syne/ANC-1 in Muscular Dystrophy? This model
points out the similarities between the mechanisms of Syne/ANC-1 and
dystrophin. Both of these huge proteins bind to actin through N-terminal
calponin domains, and extend spectrin repeats through the cytoplasm. Both then
function as part of a bridge across membranes. Mutations in many of these
components lead to muscular dystrophy (see text).
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