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Fig. 1. Three-dimensional structure of ribonuclease A and Onconase®. Ribbon
diagrams of (A) RNase A and (B) ONC were created using the atomic coordinates
derived by x-ray diffraction analysis
(Wlodawer et al., 1988;
Mosimann et al., 1994) and the
program MOLSCRIPT (Kraulis, 1991). The location of the active site clefts and
residues 19 (RNase A) and 16 (ONC), which were replaced with cysteine for
labeling experiments, are indicated.
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