spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 11. Model of the cytotoxic internalization of ribonucleases. RNase A and ONC bind to the cell surface and are internalized by dynamin-independent endocytosis. Like diptheria toxin, both ribonucleases probably reach the cytosol by translocation from an endosome. Unlike diphtheria toxin, the low pH of acidic endosomes is not a prerequisite for the translocation of RNase A and ONC to the cytosol. The entry of ONC to the Golgi is inefficient for cytotoxicity. Unlike ricin and Shiga toxin, both ribonucleases reach the cytosol by translocation from a pre-ER compartment.





Right arrow Return to article