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First published online September 12, 2003

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Bcl-2 in brief

Members of the Bcl-2 family are key regulators of apoptosis. Proteins such as C. elegans CED-9, Bcl-x_L and Bcl-2 itself promote cell survival, but others - for example, Bid, Bax and Bcl-G_s - are pro-apoptotic. If that wasn't confusing enough, these molecules respond to numerous different stimuli, such as DNA damage, Ca²⁺ and cytokine deprivation, and their antagonistic roles are the subject of considerable debate. Help is at hand, however. In Cell Science at a Glance (see p. 4053 + poster), David Huang and co-workers provide a survey of the Bcl-2 proteins, including the various Bcl-2 homology (BH) domains they contain and current models for how they regulate cell death and cell survival.

Related articles in JCS:

The Bcl-2-regulated apoptotic pathway

Simon Willis, Catherine L. Day, Mark G. Hinds, and David C.S. Huang
JCS 2003 116: 4053-4056. [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content