Fig. 11. (A) Diagram showing how merotelic kinetochore orientation might be favored in chromosomes oriented with their centromere axis perpendicular to the interpolar spindle axis. (B) The aurora B/INCENP complex might play a role in merotelic orientation correction because of its proximity to the part of the merotelic kinetochore attached to the incorrect pole. (C) Correct chromosome segregation in the presence of merotelic orientation can occur either because the pulling force in one direction prevails on the force in the opposite direction (middle) or because the pulling forces on the kinetochore induce its breakage (bottom).

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