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Fig. 8. Examples of merotelic kinetochore orientations in prometaphase/metaphase analyzed by confocal microscopy and 3D image deconvolution. Images on each row show three different angles of the same cell. Arrows indicate merotelically oriented kinetochores. Note that when a merotelically oriented kinetochore is present, it appears still connected to kinetochore microtubules coming from both poles when the image is rotated of 12° (middle column) and 24° (right column). CTRL, control; NOC-R, 30 minutes recovery from a nocodazole-induced mitotic arrest; MG-132, 2 hours treatment with 5 µM MG-132; NOC-R + MG-132, nocodazole (2 µM) mitotic arrest + 25 minutes recovery + 2 hours MG-132 treatment. Scale bar: 10 µm.





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