Fig. 3. The double ring model of cytokinesis positioning. Centralspindlin complexes move to the midzone along microtubules where they concentrate and activate the RhoGEF through a direct protein-protein interaction. This leads to a cortical ring of activated Rho1 between the separated chromosomes. The activated Rho1 leads to formation and activation of the actomyosin contractile ring (not shown).

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